The annual event features speeches and panel discussions that address the central question, "Can Women Save the World?" Winfrey's response is that women have been doing exactly that for so many years.
She says women should continue to "rock the boat" and redefine the message that's positive, ambitious, inclusive and "brimming with hope." The summit runs through April 12. Also on Wednesday, it was announced that Oprah and Britain's Prince Harry are creating a documentary series on mental health for Apple's new streaming service.