Chambers' last episode aired Nov. 14. Chambers said in a statement he has “hoped to diversify my acting roles and career choices. And, as I turn 50 and am blessed with my remarkable, supportive wife and five wonderful children, now is that time.” He thanked ABC, show creator Shonda Rimes, the original cast members, the rest of the cast and crew and fans "for an extraordinary ride.”
Other actors who have left the show include Sandra Oh, Patrick Dempsey, Katherine Heigl, T.R. Knight and Isaiah Washington. “Grey's Anatomy” is ABC's No. 1 scripted drama in its 16th season. Chambers has had roles on NBC's “Another World,” and the film “The Wedding Planner.” He won a People's Choice Award in 2017.