The TV station said Tuesday's explosion occurred mid-afternoon in the city's Al-Hammam Square, which is usually crowded with people. It said specialized units dismantled a second bomb before it detonated in the same location.
Footage broadcast on TV showed people gathered around the wreckage of a smoldering car. Latakia has been a government stronghold since the Syrian conflict began in March 2011. The blast came two days after an explosion struck a neighborhood in the capital Damascus. State media said there were no casualties in Sunday's explosion.
Syria's war which started in 2011 has killed nearly half a million people and forced more than half its pre-war population from their homes.