Mbappe served the first of his three-match ban while Neymar was rested by coach Thomas Tuchel after playing with Brazil in a friendly game against El Salvador midweek in the United States. Without his two star players, Tuchel gave Julian Draxler a start, a move that paid off as the German international put the hosts in front with a header in the 22nd minute after a long pass by Marco Verrati.
Edinson Cavani made it 2-0 in the 51st after being fouled in the area for his third goal this season, and Angel Di Maria added the third near the end with a powerful left-footed shot from a tight angle. Substitute forward Moussa Diaby completed the win with his first goal in the top tier in the 84th.
PSG handed 10-time champion Saint-Etienne its first loss this season and extended its lead over second-placed Dijon to six points. Dijon hosts Angers on Saturday. Tuchel, who was appointed this summer as a replacement for Unai Emery, set a new club record by becoming the first coach to win his five opening league matches in his first season.
Earlier, Nice defeated Rennes 2-1 with goals by Allan Saint-Maximin and Pierre Lees-Melou.
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