The club did not say exactly how long the players will be out of action, be it should take at least three weeks for their recovery. Vazquez had to be replaced in the first half of Madrid's 4-1 loss to Ajax on Tuesday at Santiago Bernabeu Stadium, a result that eliminated the team in the round of 16 of the Champions League.
Vinicius Junior, who was also hurt in the first half against Ajax, will be out for about two months because of a right ankle injury. Madrid has lost three matches in a row in all competitions. It has also been knocked out from the Copa del Rey, and is 12 points behind leader Barcelona with 12 matches left in the Spanish league.
Madrid's next game is Sunday at relegation-threatened Valladolid.
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