Saints captain Pierre-Emile Hojbjerg earned the visitors victory at Amex Stadium by scoring his first goal since December. Southampton winger Nathan Redmond's driving run and perfectly weighted pass slipped Hojbjerg in on goal and he produced a composed poke past Mathew Ryan and into the bottom right corner in the 53rd minute.
Brighton almost leveled when right back Martin Montoya crashed a shot against the crossbar from the edge of the box with 18 minutes to go. Chris Hughton's side, which grabbed a last-gasp equalizer at St Mary's in September, was unable to salvage a draw.
The result moved Southampton level on points with the Seagulls, five above the drop zone ahead of 18th-placed Cardiff's clash with Chelsea on Sunday.
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