He missed the team's 1-0 loss to Athletic Bilbao in the league opener on Friday. Barcelona has not said how long it expects Messi to be sidelined. Coach Ernesto Valverde is also dealing with injuries to forwards Luiz Suárez and Ousmane Dembele.
Dembele is certain to miss Sunday's match at the Camp Nou because of a left thigh injury that should keep him out for about five weeks. Suárez also isn't likely to play this weekend because of a muscle injury sustained before halftime of Friday's game in Bilbao.
Two-time defending champion Barcelona hadn't loss a league opener in 10 seasons.
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