The Catalan club has already secured a spot in the knockout stage as the group leader. It has four more points than Inter Milan and Borussia Dortmund, which hosts already eliminated Slavia Prague. Only the top two in each group advance to the round of 16.
Valverde is also resting defender Gerard Piqué and midfielder Sergi Roberto. Out injured are Ousmane Dembele, Arthur, Jordi Alba, and Nelson Semedo. Among those who made the trip to Italy are Luis Suárez, Antoine Griezmann, and teenager Ansu Fati.
Messi scored a hat trick on Saturday in Barcelona's 5-2 win over Mallorca in the Spanish league.
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