The round of 16 will still be played in single-elimination games. Only the semifinals will be decided with a home-and-away series this season. Madrid will play at Zaragoza, while Barcelona will host Leganés.
There were no restrictions involving the top-flight teams in the draw, except that the the lower-division clubs would get to play at home. Zaragoza got past top-flight team Mallorca in the round of 32, while relegation-threatened Leganés ousted third-tier club Ebro. Barcelona and Madrid eliminated third-division clubs Ibiza and Unionistas de Salamanca, respectively.
The only other matchup between first-division clubs will be Real Sociedad versus Osasuna. In other games between first- and second-division clubs, Sevilla will take on Mirandes, Athletic Bilbao will face Tenerife and Villarreal will play against Rayo Vallecano.
Badajoz, the other third-division club in the draw, will host Granada. Eight first-division teams were eliminated in the round of 32: Atlético Madrid, Real Betis, Eibar, Celta Vigo, Valladolid, Espanyol, Levante and Mallorca.
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