The ban blocks American companies and individuals from doing business with Maduro's government and its top supporters. It came Monday night as an executive order from President Donald Trump and takes effect immediately.
Trump's order spares Venezuela's still sizable private sector. Yet it represents the most sweeping U.S. action to remove Maduro since the Trump administration recognized opposition leader Juan Guaidó as Venezuela's rightful leader in January.
The order also exposes foreign entities doing business with the Maduro government to U.S. retaliation.