The launch of surface-to-surface, medium-range missiles into Syria's Deir el-Zour province comes as Islamic State militants fleeing a U.S.-led coalition onslaught increasingly try to fortify their positions there.
Activists in Syria said they had no immediate information on damage or casualties from the strikes, launched from Iran's Kurdistan and Kermanshah provinces. Social media was awash in shaky mobile phone footage from those areas, allegedly showing the missiles rise in an orange glow before heading toward their targets.
Sunday's assault marked an extremely rare direct attack from inside the Islamic Republic amid its support for embattled Syrian President Bashar Assad. Iran's Revolutionary Guard, a hard-line paramilitary force, has seen advisers and fighters killed in the conflict.
A Guard statement carried on its website said many "terrorists" were killed and their weapons had been destroyed in the strike. It described targeting a command center and an area used to build suicide car bombs in the provincial capital, also named Deir el-Zour.
"The message of the revolutionary and punishing move is totally clear," the Guard said in its statement, carried by the state-run IRNA news agency. "If the evil and satanic measures against the Iranian nation are repeated, the revolutionary anger and flames of (the Guard's) revenge will engulf the perpetrators and lead the criminals to hell."
Iran's semi-official Fars news agency, believed to be close to the Guard, said the paramilitary force launched a total of six missiles that flew over Iraqi airspace before striking Syria. Deir el-Zour is home to both Islamic State militants and civilians. The extremists increasingly have fled to Deir el-Zour as the Islamic State group's de facto capital of Raqqa has come under punishing U.S.-led airstrikes.
Five Islamic State-linked attackers stormed Iran's parliament and a shrine to revolutionary leader Ayatollah Ruhollah Khomeini on June 7, killing at least 18 people and wounding more than 50. That attack marked the first to hit Iran, shocking its residents who believed the chaos engulfing the rest of the Middle East would not find them in the Shiite-majority nation.
Iran has described the attackers as being "long affiliated with the Wahhabi," an ultraconservative form of Sunni Islam practiced in Saudi Arabia. However, it stopped short of directly blaming the kingdom for the attack, though many in the country expressed suspicion Iran's regional rival had a hand in the attack.
The attack also came as emboldened Sunni Arab states — backed by U.S. President Donald Trump — are hardening their stance against Iran. The Guard, which is also involved in the fight against the Islamic State group in neighboring Iraq, controls Iran's missile program. It has test-fired a number of missiles since Iran struck the 2015 nuclear deal with world powers, including the U.S.
Since Trump took office, his administration has described putting Iran "on notice" over the missile tests and put new economic sanctions on those allegedly involved with the program. Israel also remains concerned about Iran's missile launches.
Associated Press writers Jon Gambrell in Dubai, United Arab Emirates, and Sarah El Deeb in Beirut contributed to this report.