Sharpless currently heads the National Institutes of Health's cancer division, which directs billions in federal funding and grants for research. His name has been circulated as one of several government officials likely to succeed Gottlieb on a permanent basis.
Health and Human Services Secretary Alex Azar said the search for a new FDA commissioner is underway. The FDA's top official is nominated by the president and must be confirmed by the Senate, typically following public hearings before health lawmakers.
Last Tuesday, Gottlieb said he would step in down in April after less than two years leading the FDA, a massive public health agency that regulates the food, drug, medical device and tobacco industries, among others. He was widely viewed as one of President Donald Trump's most effective administrators, serving as a key messenger on the federal response to rising drug prices, the opioid epidemic and underage use of e-cigarettes.
Gottlieb said he wants to spend more time with his family after commuting weekly to Washington from his home in Connecticut. During his tenure, Gottlieb launched a series of ambitious public health initiatives, including a plan to make cigarettes less addictive by drastically cutting nicotine levels. But that plan and many others have barely progressed beyond the earliest stages, raising questions about their timeline and prospects for completion. FDA commissioners report to the White House, but generally have broad leeway to choose their priorities.
Sharpless has publicly supported FDA's efforts to more tightly regulate tobacco and crack down on underage vaping. E-cigarettes are generally viewed as less harmful than traditional tobacco products, but they usually contain nicotine which can harm the adolescent brain. Some research also suggests that teenagers who use e-cigarettes are more likely to try regular cigarettes.
Sharpless has led the National Cancer Institute since October 2017. He previously was a professor and administrator at the University of North Carolina, where he also earned his medical degree in 1993.
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